ABSTRACT
<p><b>OBJECTIVE</b>To explore in vivo metabolic changes in abnormal savda patients with different types of tumor.</p><p><b>METHODS</b>A total of 142 abnormal savda patients with common cancer types were enrolled in this study, and 50 healthy volunteers were recruited as the control group. For each sample, the H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed. The free attenuation signal was computed subsection integral. Data obtained were analyzed by the Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA).</p><p><b>RESULTS</b>Compared with the control group, leucine, isoleucine, valine, histidine, phenylalanine, tyrosine, alanine, creatine, lactic acid, inositol, alpha-and beta-glucose, unsaturated lipids, very low density lipoprotein (VLDL) significantly decreased (P <0.05), while glycoprotein and carnitine significantly increased (P <0. 05) in the abnormal Savda group.</p><p><b>CONCLUSION</b>Abnormal savda patients with different types of tumor had similar metabonomics changes.</p>